表观遗传修饰(epigeneticmodification),如DNA甲基化、组蛋白乙酰化和甲基化、RNA相关性沉默与细胞生长、分化、凋亡、转化及肿瘤进展相关基因的转录密切相关。白血病的发生和发展与表观遗传修饰异常直接相关。本文综述细胞周期调节基因甲基化,组蛋白翻译后修饰异常及siRNA对白血病细胞的作用,为白血病治疗提供新策略。 Epigenetic modifications such as DNA methylation, histone acetylation and methylation, RNA-related silencing are closely related to the transcription of genes involved in cell growth, differentiation, apoptosis, transformation and tumor progression. The occurrence and development of leukemia is directly related to abnormal epigenetic modification. This review summarizes the role of methylation of the cell cycle regulatory genes, posttranslational modifications of histone and siRNA on leukemic cells, providing new strategies for the treatment of leukemia.