论文部分内容阅读
47例高血压病伴左室肥厚者入选。患者停用降压药物2周后随机分为两组:A组(25例)投以培哚普利4mg～8mg,每日一次晨服;B组(22例)美托洛尔每日50mg～125mg,分2次口服,疗程8周。治疗前两组左室重量指数(LVMI)无差异。A组LVMI的降低出现在药后4周,8周后更为明显(从143.2±21.3g/m~2降至126.6±15.3g/m~2,P<0.001),而B组LVMI的降低出现在药后8周(从140.6±23.7g/m~2降至133.4±13.2g/m~2,P<0.001),此外药后8周两组LVMI差异显著(P<0.05)。两组E/A比值显著增加(P<0.001)。研究表明两药短期治疗均可引起LVH逆转伴左室舒张功能改善,培哚普利对LVH的逆转较美托洛尔更为有效。
47 cases of hypertensive patients with left ventricular hypertrophy were selected. The patients were randomly divided into two groups after antihypertensive drugs were discontinued for 2 weeks: Group A (25 cases) was given perindopril 4mg ~ 8mg once a day for morning wear; Group B (22 cases) metoprolol daily 50mg ~ 125mg, 2 times orally, course of treatment for 8 weeks. There was no difference in left ventricular mass index (LVMI) between the two groups before treatment. The decrease of LVMI in group A appeared after 4 weeks of treatment and more significantly after 8 weeks (from 143.2 ± 21.3 g / m 2 to 126.6 ± 15.3 g / m 2, P <0.001), while the LVMI in group B decreased (P <0.001) after 8 weeks of treatment (from 140.6 ± 23.7 g / m ~ 2 to 133.4 ± 13.2 g / m ~ 2, P <0.001). E / A ratio increased significantly between the two groups (P <0.001). Studies have shown that short-term treatment of both drugs can cause LVH reversal with left ventricular diastolic function improvement, perindopril reversal of LVH is more effective than metoprolol.