论文部分内容阅读
目的探讨功能性消化不良（ｆｕｎｃｔｉｏｎａｌ ｄｙｓｐｅｐｓｉａ， ＦＤ）患者体表胃电参数与血浆胃肠激素的变化及其在ＦＤ发病中的可能作用及临床意义。方法对５８例ＦＤ患者与１５例健康对照者进行体表胃电图检测，同期应用放免法测定患者空腹血浆胃动素（ＭＴＬ）、生长抑素（ＳＳ）、胆囊收缩素（ＣＣＫ）含量；并对２０例ＦＤ患者经西沙比利治疗前后胃电图（主频Ｆｐ和振幅Ａｐ）及血浆胃肠激素含量变化进行了观察。结果①ＦＤ组体表胃电参数为平均振幅［（１７９．００±６２．７０）μＶ］与主频［（１．９０±０．７４）ｃｐｍ］均较对照组低（２７４．００±４０．５０；２．７６±０．２６，Ｐ＜０．０１）；ＦＤ组基础血浆胃动素［（３８０．６６±７１．２８）ｐｇ／ｍｌ］低于正常组（４７０．６４± ５４．１６，Ｐ＜０．０５），胆囊收缩素［（５６．５９±１２．９３）ｐｇ／ｍｌ］与生长抑素［（６３．９１±１２．７１）ｐｇ／ｍｌ］则高于正常组（３９．３３±７．７６；４７．３２±６．４４，Ｐ＜０．０１）。②ＦＤ患者Ａｐ和Ｆｐ与ＭＴＬ呈正相关，与ＣＣＫ及ＳＳ呈负相关。③症状积分高低依次为腹胀、早饱、上腹痛、嗳气、反酸烧心、恶心呕吐。症状与体表胃电及血浆胃动?
Objective To investigate the changes of gastric electrical parameters and plasma gastrointestinal hormones in patients with functional dyspepsia (FD) and its possible role in the pathogenesis of FD and its clinical significance. Methods Fifty-eight patients with FD and 15 healthy controls were examined by electrogastrography. The levels of fasting plasma motilin (MTL), somatostatin (SS) and cholecystokinin (CCK) were measured by radioimmunoassay in the same period. The changes of the electrogastrogram (frequency Fp and amplitude Ap) and the content of plasma gastrointestinal hormone in 20 FD patients before and after treatment with cisapride were observed. Results ① The mean gastric electrical parameters of the body surface in the FD group were lower than those in the control group [(179.00 ± 62.70) μV] and the dominant frequency [(1.90 ± 0.74) cpm], respectively (274.00 ± 40. 50; 2.76 ± 0.26, P <0.01). The basal plasma motilin in the FD group [(380.66 ± 71.28) pg / ml] was lower than that in the normal group (470.64 ± 54.16 , P <0.05). The levels of cholecystokinin [(56.59 ± 12.93) pg / ml] and somatostatin [(63.91 ± 12.71) pg / ml] .33 ± 7.76; 47.32 ± 6.44, P <0.01). ② In patients with FD, Ap and Fp were positively correlated with MTL and negatively correlated with CCK and SS. ③ symptom score followed by abdominal distension, early fullness, abdominal pain, belching, heartburn acid reflux, nausea and vomiting. Symptoms and body surface Gastric and gastric motility?