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目的 探讨肺结核患者T淋巴细胞亚群与核仁组成区嗜银蛋白 (AgNORs)的关系 ,并动态观察临床应用的价值。方法 采用碱性磷酸酶抗碱性磷酸酶 (APAAP)法及AgNORs测定方法 ,对 98例肺结核患者 ,3 9例肺炎患者和 41名正常人分别测定外周血T淋巴细胞亚群和AgNORs,并对 71例初治肺结核患者进行了动态观察。结果 肺结核患者的CD+ 3 、CD+ 4 、CD+ 4 /CD+ 8比值均明显降低 ,CD+ 8升高 ;AgNORs的I.S %值明显降低 ,与健康人及肺炎患者相比有显著性差异 (P <0 .0 1 )。随着肺结核患者病情的好转此两项指标逐渐上升。结论 肺结核患者T淋巴细胞亚群与AgNORs检测结果一致 ,可动态地反映结核病人的免疫状态 ,并与病情发展呈良好的相关性 ,可作为指导治疗的参考
Objective To investigate the relationship between T lymphocyte subgroups and AgNORs in patients with pulmonary tuberculosis (TB) and to observe the value of clinical application. Methods Peripheral blood T lymphocyte subsets and AgNORs were detected in 98 patients with pulmonary tuberculosis, 39 patients with pneumonia and 41 normal persons by alkaline phosphatase-resistant alkaline phosphatase (APAAP) assay and AgNORs assay. 71 cases of newly diagnosed tuberculosis patients were observed. Results The ratios of CD + 3, CD 4, CD 4 / CD 8 in patients with pulmonary tuberculosis were significantly lower than those in patients with pulmonary tuberculosis (P <0.05). The percentage of IS% in AgNORs was significantly lower than that in healthy people and pneumonia patients. 0 1). With the improvement of patients with tuberculosis these two indicators gradually increased. Conclusion The results of T lymphocyte subsets in patients with tuberculosis are consistent with that of AgNORs, which can dynamically reflect the immune status of patients with tuberculosis and have a good correlation with the progression of the disease, which can be used as a reference guide