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妊娠是一个复杂而又协调的生理过程,母-胎界面正常免疫耐受的建立和维持是妊娠成功与否的关键。母体胎盘、激素水平、黏附分子、细胞因子、人类白细胞抗原、自然杀伤细胞、调节性T淋巴细胞等在母-胎免疫耐受过程中均有重要作用。此外,吲哚胺2,3-双加氧酶作为一种分解代谢酶,其自身的表达调控及其与多种免疫因子、免疫细胞的相互作用在妊娠免疫耐受中也发挥着重要而复杂的作用。
Pregnancy is a complex and coordinated physiological process. The establishment and maintenance of normal immune tolerance at the maternal-fetal interface is the key to the success of pregnancy. Maternal placenta, hormone levels, adhesion molecules, cytokines, human leukocyte antigens, natural killer cells, regulatory T lymphocytes play an important role in the process of mother-fetar immune tolerance. In addition, indoleamine 2,3-dioxygenase as a catabolic enzyme, its own expression and regulation and its interaction with a variety of immune factors, immune cells also play an important and complex pregnancy immune tolerance Role.