近几年来,许多学者对血细胞尤其是粒细胞生成的调节,进行了大量的体外和动物实验研究,认为调节血细胞生成的因子主要作用于单能定型干细胞阶段。现已发现组织、器官中存在促使粒细胞的单能定型干细胞向着粒细胞方向分化的粒细胞生成素,其中特别对来沅于单核细胞—巨噬细胞系统的集落刺激因子,研究得最多。一、集落形成细胞:将小白鼠、猴子或人的骨髓培养在半固体组织培养基中,或将 In recent years, many scholars on the regulation of blood cells, especially granulocytes, carried out a large number of experimental studies in vitro and animal studies, that the regulation of hematopoietic factors mainly in the mononuclear stem cells stage. It has been found that in tissues and organs there are granulopoietin that promote the differentiation of monocytes from the granulocytes toward the granulocytes. Among them, the most studied are the colony stimulating factors from the Yuan-yuan to the monocyte-macrophage system. First, the colony forming cells: mouse, monkey or human bone marrow cultured in semi-solid tissue culture medium, or