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Objective:To study the effect of Jinguo Weikang Capsule (金果胃康胶囊,JWC) on the gene expression of H-ras,epidermal growth factor receptor (EGFR),P53 and C-myc of the gastric mucosa in rats with gastric precancerous lesions,and to investigate the action mechanism of JWC on gastric precancerous lesions.Methods:A rat model with paratypical proliferation of the gastric epithelium mucosa was established by using 60Co irradiation.Rats were divided into the normal group,model group,high-,medium-,low-dose JWC treatment groups,and the vitacoenzyme control group,and were treated for 30 days.The expression of H-ras,EGFR,P53 and C-myc genes of the gastric mucosa was detected by using immunohistochemical methods.Results:The expression and over-expression rates of H-ras,EGFR,P53 and C-myc gene in the high- and medium-dose JWC treatment groups were significantly lower (P＜0.05)as compared with those of the model group.Conclusion:JWC can inhibit the expression of the H-ras,EGFR,P53 and C-myc genes expression of the gastric mucosa in rats,which may be one of mechanisms involved in suppressing or reversing gastric carcinogenesis.