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目的探讨血管内皮生长因子在外阴上皮内非瘤样病变、外阴上皮内瘤样病变及外阴鳞状细胞癌中的表达及其临床意义。方法采用免疫组织化学方法检测VEGF在外阴上皮内非瘤样病变40例(包括外阴鳞状上皮细胞增生20例及外阴硬化性苔藓20例)、VIN20例及外阴鳞状细胞癌20例中的表达。结果VEGF在VIN中阳性表达率为35%,在外阴鳞状细胞癌中阳性表达率为80%,两者间具有显著差异性(P<0.05)。结论VEGF促进了VIN和外阴鳞状细胞癌新血管生成,在外阴癌变的过程中起到了重要作用。
Objective To investigate the expression of vascular endothelial growth factor in vulvar intraepithelial neoplasia, vulvar intraepithelial neoplasia and vulvar squamous cell carcinoma and its clinical significance. Methods Immunohistochemistry was used to detect the expression of VEGF in 40 cases of vulvar intraepithelial neoplasia (including 20 cases of vulvar squamous cell hyperplasia and 20 cases of vulvar vulvar lichen sclerosus), 20 cases of VIN20 and vulvar squamous cell carcinoma . Results The positive rate of VEGF expression in VIN was 35%, while that in vulvar squamous cell carcinoma was 80%. There was a significant difference between the two (P <0.05). Conclusion VEGF promotes angiogenesis of VIN and vulvar squamous cell carcinoma and plays an important role in the carcinogenesis of vulva.