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目的:分析氨茶碱常规剂量用于治疗不同胎龄儿呼吸暂停与其血药浓度的相关性。方法:选取新生儿科2011年8月—2014年6月间收治的早产儿呼吸暂停患者80例的病历资料,分析氨茶碱常规剂量用于治疗早产儿呼吸暂停患者与其血药浓度的相关性。结果:不同胎龄早产儿呼吸暂停发生率经比较其差异有统计学意义(P<0.05);其胎龄越小呼吸暂停的发生率越高;患儿胎龄越小氨茶碱常规用量治疗中的血药浓度越高;伴随着患儿胎龄的增长,氨茶碱血药浓度逐渐下降;氨茶碱常规剂量用于治疗不同胎龄呼吸暂停患儿与其血药浓度存在一定的相关性(r=0.56,P<0.05)。结论:治疗早产儿呼吸暂停采用氨茶碱常规剂量并结合患儿胎龄,应监测治疗药物血药浓度,降低不良反应的发生,提高用药安全性。
Objective: To analyze the relativity between routine dose of aminophylline and apnea for different gestational age children. Methods: 80 cases of apnea in premature infants admitted from August 2011 to June 2014 in neonatology were enrolled in this study. The routine dose of aminophylline was used to analyze the correlation between the conventional dose of aminophylline and the blood concentration of apnea in preterm infants. Results: The incidence of apnea in different gestational age preterm infants was significantly different (P <0.05). The smaller the gestational age, the higher the incidence of apnea. The smaller the gestational age, the smaller the conventional dose of aminophylline In the plasma concentration of the higher; accompanied by the growth of children with gestational age, aminophylline plasma concentration gradually decreased; routine doses of aminophylline for treatment of children with different gestational age apnea and plasma concentrations there is a certain correlation (r = 0.56, P <0.05). Conclusion: The treatment of preterm infants with apnea routine dose of aminophylline combined with the gestational age of children, the drug concentration should be monitored to reduce the incidence of adverse reactions and improve drug safety.