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作者采用癌灶多点取材法,对食管癌患考癌细胞DNA含量进行了分析。结果表明,患者癌细胞DNA异倍体和多异倍体检出率和随机一点取材法相比,分别增加了50%和3.5倍。用该取材法还可以检测患者的DNA倍体异质性和DNA干系的分布情况。
The authors used multi-point sampling methods to analyze the DNA content of cancer cells in esophageal cancer patients. The results showed that the detection rate of DNA aneuploidy and heteroploidy in patients with cancer cells was increased by 50% and 3.5 times, respectively, compared with that obtained by a random point method. Using this method of extraction can also detect the patient’s DNA ploidy heterogeneity and distribution of DNA stems.