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尽管多数甲状腺癌预后较好,但依然有部分患者死于转移和复发~([1-4])。结合触诊、B超、核素显像及细针穿刺细胞学活检(fine needle aspiration cytology,FNAB)等对甲状腺癌进行综合评价可在一定程度上提高诊断和推断预后的精准性,但仍存在困难~([5])。随着分子水平和蛋白水平对肿瘤的研究进展,与甲状腺癌发生、发展、转归和预后有关的肿瘤标志物近年颇受关注,理想的肿瘤标志物应该具有特异性高、敏感性强、可信性高的特点。现就近年常用的肿瘤标志物在甲状腺癌的诊断和评估中的临床意义作一回顾。
Although most thyroid cancers have a good prognosis, some patients still die of metastases and relapses ([1-4]). Combining palpation, B-ultrasonography, radionuclide imaging and fine needle aspiration cytology (FNAB) for comprehensive evaluation of thyroid cancer can improve diagnosis and infer prognosis accuracy to a certain extent, but it still exists. Difficult ~ ([5]). With the progress of molecular and protein levels in tumor research, tumor markers related to the occurrence, development, prognosis and prognosis of thyroid cancer have received considerable attention in recent years. The ideal tumor markers should have high specificity and sensitivity. Confidence characteristics. The clinical significance of the commonly used tumor markers in recent years in the diagnosis and evaluation of thyroid cancer is reviewed.