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目的考察临床上应用全肠外营养液配方中的不溶性微粒以及配伍的合理性。方法按照临床常用的全肠外营养液配方配制,分别考察配制后的渗透压和1、4和12 h溶液中的不溶性微粒变化。结果全肠外营养液加入注射用脂溶性维生素(Ⅱ)/注射用水溶性维生素后,不溶性微粒急剧增加,其中大于10μm的不溶性微粒超过标准的10倍以上。维生素C、电解质和微量元素也存在影响。结论分析全肠外营养液中不溶性微粒形成的原因,对提高其配置质量,减少不溶性微粒对患者的损害,具有重大的临床意义。
Objective To investigate the clinical application of total parenteral nutrition solution of insoluble particles and the compatibility of compatibility. Methods According to the commonly used formulas of total parenteral nutrition solution, the changes of osmotic pressure and insoluble particles in 1,4 and 12 h solution were investigated. Results After the total parenteral nutrition solution was added into the fat-soluble vitamin (II) for injection / water-soluble vitamin for injection, the insoluble particles increased sharply, and the insoluble particles larger than 10μm exceeded the standard by more than 10 times. Vitamin C, electrolytes and trace elements are also affected. Conclusion It is of great clinical significance to analyze the cause of formation of insoluble particles in total parenteral nutrition solution to improve the configuration quality and reduce the damage of insoluble particles to patients.