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目的:比较不同类型宫颈癌患者宫颈鳞状上皮中人乳头瘤状病毒(HPV)负荷量,揭示HPV负荷量用于评价宫颈癌严重程度的潜在价值。方法:对不同类型的宫颈上皮内瘤变及宫颈癌患者2 718例采用Hybrid Capture2 High-Risk HPVDNA Test检测不同类型患者鳞状上皮组织中HPV负荷量,统计各组的1≤HPV DNA<100、100≤HPV DNA<500、500≤HPV DNA<1 000和HPV DNA≥1 000的比例。结果:217例健康妇女中HPV DNA<1的有215例,显著高于其他各组(P<0.05);CINⅠ、CINⅡ和CINⅢ组1≤HPV DNA<100的比例分别为80.40%、70.65%和77.29%,均显著高于其他各组(P<0.05);原位癌组100≤HPV DNA<500比例占51.58%,显著高于其他各组的比例(P<0.05);浸润癌Ⅰ、Ⅱ和Ⅲ期组500≤HPV DNA<1 000比例分别占77.23%、77.20%和75.52%,均显著高于其他各组(P<0.05);浸润期IV期HPV DNA>1 000比例占68.67%,均显著高于其他各组的比例(P<0.05)。结论:HPV负荷量检测可区分正常宫颈、CIN、原位癌和浸润癌,具有潜在评价宫颈癌严重程度的临床价值。
Objective: To compare the human papillomavirus (HPV) load in different types of cervical cancer patients with cervical squamous epithelium and to reveal the potential value of HPV load in evaluating the severity of cervical cancer. Methods: Totally 2 718 cases of cervical intraepithelial neoplasia and cervical cancer with Hybrid Capture2 High-Risk HPVDNA Test were used to detect the HPV load in squamous epithelium of different types of patients. 1≤HPV DNA <100, 100 1000. Results: Among 215 healthy women, there were 215 cases with HPV DNA <1, which were significantly higher than those in other groups (P <0.05). The ratios of 1 ≤ HPV DNA <100 in CINⅠ, CINⅡand CINⅢgroup were 80.40% and 70.65% 77.29%, all of which were significantly higher than those in other groups (P <0.05). The percentage of 100≤ HPV DNA <500 in situ carcinoma group was 51.58%, significantly higher than that in other groups (P <0.05) (P <0.05). The proportion of HPV DNA> 1 000 in stage IV infiltration accounted for 68.67%, which was significantly higher than that in other groups (77.23%, 77.20% and 75.52%, respectively) Were significantly higher than the other groups (P <0.05). Conclusion: The detection of HPV load can distinguish normal cervical, CIN, carcinoma in situ and invasive carcinoma, which has the potential value of evaluating the severity of cervical cancer.