Huntington’s disease(HD)is the most common dominantly inherited neurodegenerative disorder,mainly characterized by the progressive striatal and cortical neurodegeneration and associated motor,cognitive and behavioural disturbances(Zuccato et al.,2010).The disease-causing mutation is an expansion of a CAG trinucleotide repeat(>36 repeats)encoding a polyglutamine stretch in the N-terminal region of huntingtin(Htt)(Zuccato et al.,2010),a ubiquitous protein whose function is still Huntington’s disease (HD) is the most common dominantly inherited neurodegenerative disorder, mainly characterized by the progressive striatal and cortical neurodegeneration and associated motor, cognitive and behavioral disturbances (Zuccato et al., 2010). The disease-causing mutation is an expansion of a CAG trinucleotide repeat (> 36 repeats) encoding a polyglutamine stretch in the N-terminal region of huntingtin (Htt) (Zuccato et al., 2010), a ubiquitous protein whose function is still