研究了替硝唑-β-环糊精包合物的制备工艺及替硝唑包合前后物理性能的变化。结果表明:替硝唑和包合物(研磨法、饱和溶液法)T_(50)分别为12.90和1.68、3.51min,Td分别为19.60和2.88、5.70min。包合物在30℃时的溶解度研磨法和饱和溶液法分别为11.06和8.33mg·ml~(-1),比包合前的5.46mg·ml~(-1)增大了1倍和0.6倍以上。结论:包合后溶解度和溶出度均增加。 The preparation process of tinidazole-β-cyclodextrin inclusion compound and the change of physical properties before and after tinidazole inclusion were studied. The results showed that the T_ (50) of tinidazole and inclusion complex (grinding method, saturated solution method) were 12.90 and 1.68, 3.51min respectively, and the Td was 19.60 and 2.88,5.70min respectively. The solubility of the inclusion complex at 30 ℃ and the saturated solution method were 11.06 and 8.33 mg · ml -1, respectively, which were two times larger than that of 5.46 mg · ml -1 before inclusion Times more. Conclusion: After inclusion, the solubility and dissolution increased.