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目的研究并探讨缺血性脑血管病患者血浆生长素(Ghrelin)水平的表达及其临床意义。方法 80例缺血性脑血管病患者设为观察组,50例健康体检者设为对照组,所有受检者均接受血浆生长素检测。比较观察组与对照组、脑梗死患者与短暂性脑缺血发作患者、不同面积脑梗死患者的血浆生长素水平,并分析血浆生长素与缺血性脑血管病的相关性。结果观察组血浆生长素水平为(67.35±10.87)ng/L,明显低于对照组的(85.46±14.59)ng/L,差异具有统计学意义(P<0.05)。脑梗死患者血浆生长素水平明显低于短暂性脑缺血发作患者,差异具有统计学意义(P<0.05)。不同面积脑梗死患者的血浆生长素水平比较,差异有统计学意义(P<0.05)。经相关性分析,血浆生长素水平与缺血性脑血管病呈负相关(r=-0.716,P<0.05)。结论缺血性脑血管病的发生可能与血浆生长素水平降低有关,血浆生长素水平降低在一定程度上会对脑缺血性损伤予以加重。
Objective To study and discuss the expression of Ghrelin in patients with ischemic cerebrovascular disease and its clinical significance. Methods Eighty patients with ischemic cerebrovascular disease were enrolled as observation group and 50 healthy subjects as control group. All subjects received plasma auxin. The plasma levels of auxin were compared between the observation group and the control group, patients with cerebral infarction and transient ischemic attack, and with different area of cerebral infarction. The correlation between plasma auxin and ischemic cerebrovascular disease was analyzed. Results The level of plasma auxin in the observation group was (67.35 ± 10.87) ng / L, which was significantly lower than that in the control group (85.46 ± 14.59) ng / L, with statistical significance (P <0.05). Plasma levels of auxin in patients with cerebral infarction were significantly lower than those in patients with transient ischemic attack, the difference was statistically significant (P <0.05). The plasma levels of ghrelin in patients with different area of cerebral infarction were significantly different (P <0.05). Correlation analysis showed that the level of plasma auxin was negatively correlated with ischemic cerebrovascular disease (r = -0.716, P <0.05). Conclusions The occurrence of ischemic cerebrovascular disease may be related to the decrease of plasma auxin level. The decrease of plasma auxin level may aggravate cerebral ischemic injury to a certain extent.