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Objective: To studied the effect of Diethyldithio-carbamate (DDC) on the antitumor activity of adriamycin (ADM) nanoparticle-lipiodol emulsion. Methods: The SD rats bearing liver carcinoma were divided into six groups and treated by saline, adriamycin, adriamycin nanoparticle-lipiodol emulsion, adriamycin liposome-lipiodol emulsion,DDC plus adriamycin nanoparticle-lipiodol emulsion, DDC plus adriamycin liposome-lipiodol emulsion respectively.The volume of the tumors, tumor growth rate (G%) and life prolonging rate PL% in six groups were determined.Results: The values of the IC50 (mg/ml) of adriamycin were reduced from 18.40 to 0.74 for the resistant cellsSGC7901/CVR, and from 4.00 to 0.32 for the sensitive cells SGC7901/WT by pretreating the tumor cells with DDC. The tumor growth rate (G%) and life prolonging rate PL% increased significantly (P<0.05) in the DDC pretreatedgroups than adriamycin nanoparticle-lipiodol or adriamycin liposome-lipiodol emulsion groups. Conclusion: Theantitumor effect of adriamycin can be enhanced byinhibiting the superoxide dismutase (SOD) in tumor cells by DDC.
Methods: The SD rats bearing liver carcinoma were divided into six groups and treated by saline, adriamycin, adriamycin nanoparticle- lipiodol emulsion, adriamycin liposome-lipiodol emulsion, DDC plus adriamycin nanoparticle-lipiodol emulsion, the volume of the tumors, the tumor growth rate (G% .Results: The values of the IC50 (mg / ml) of adriamycin were reduced from 18.40 to 0.74 for the resistant cells SGC7901 / CVR, and from 4.00 to 0.32 for the sensitive cells SGC7901 / WT by pretreating the tumor cells with DDC. The tumor growth rate (G%) and life prolonging rate PL% increased significantly (P <0.05) in the DDC pretreated groups than adriamycin nanoparticle-lipiodol or adriamycin liposome-lipiodol emulsion groups. Conclusion: Theanti tumor effect of adriamycin can be enhanced by inhibiting the superoxide dismutase (SOD) in tumor cells by DDC.