论文部分内容阅读
目的:探讨甲状腺癌(TC)合并淋巴细胞性甲状腺炎(LT)的临床病理特点。方法:回顾性分析87例单纯TC(TC组)及129例TC合并LT患者临床病理资料(TC合并LT组),后者包括40例(31.0%)合并桥本氏甲状腺炎(HT),81例(62.8%)合并慢性淋巴细胞性甲状腺炎(CLT),8例(6.2%)同时合并HT与CLT。结果:所有患者均行手术治疗,根据患者病变情况分别行单侧腺叶切除、次全切除、全切除以及不同范围的淋巴结清扫术。129例TC合并LT患者中,仅1例(0.8%)为甲状腺髓样癌(MTC),其余(99.2%)均为甲状腺乳头状癌(PTC)。与TC组比较,TC合并LT组女性、微小癌、单叶受累、颈淋巴结阴性比率均明显增加,而病灶最大径明显减小(均P<0.05);在TC合并LT组中,并CLT患者与合并HT患者各项临床病理指标均无统计学差异(均P>0.05)。结论:与LT并存的TC以PTC多见,且多为女性,LT可能对TC原发灶生长及腺内、颈部淋巴结转移有抑制作用;TC合并CLT与合并HT的临床病理特征相似。
Objective: To investigate the clinicopathological features of thyroid carcinoma (TC) combined with lymphocytic thyroiditis (LT). Methods: The clinical data of 87 patients with TC (TC group) and 129 patients with TC combined with LT were retrospectively analyzed. The patients included 40 patients (31.0%) with Hashimoto’s thyroiditis (HT), 81 Cases (62.8%) with chronic lymphocytic thyroiditis (CLT), 8 cases (6.2%) combined HT and CLT. Results: All patients underwent surgical treatment. According to the patients’ condition, unilateral lobectomy, subtotal resection, total resection and different ranges of lymph node dissection were performed. Of the 129 patients with TC and LT, only 1 (0.8%) had medullary thyroid carcinoma (MTC) and the rest (99.2%) had papillary thyroid carcinoma (PTC). Compared with TC group, the ratio of female, micro-cancer, single-lobe involvement and cervical lymph node negative in TC combined with LT group increased significantly and the maximum diameter decreased significantly (all P <0.05). In TC combined with LT group and CLT patients There was no significant difference in clinical pathological parameters between patients with HT and those with HT (all P> 0.05). CONCLUSIONS: PTCs coexisting with LT are more common in patients with PTC and are mostly female. LT may inhibit the growth of TC primary tumor and lymph node metastasis in the gland. The clinical and pathological features of TC combined with CLT are similar.