流行病学研究发现,吸烟和帕金森病(Parkinsondisease,PD)发病之间存在着负相关关系,提示吸烟可能对PD具有保护作用[1]。另有研究发现,吸烟行为受遗传因素的影响,所以深入研究吸烟相关基因对吸烟和PD发病之间的负相关关系的影响,进一步从遗传学角度考证吸烟对PD保护作用的真实性 Epidemiological studies found that smoking and Parkinson’s disease (Parkinsondisease, PD) there is a negative correlation between the incidence, suggesting that smoking may have a protective effect on PD [1]. Another study found that smoking behavior is affected by genetic factors, so in-depth study of smoking-related genes on smoking and the incidence of PD, the negative correlation between the impact of smoking from a genetic perspective to further verify the authenticity of the protective effect of PD