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目的:观察睡前中效胰岛素联合口服降糖药治疗2型糖尿病的临床效果。方法:对4 5例单用口服降糖药效果欠佳的2型糖尿病患者睡前加用中效胰岛素治疗,分别测定治疗3个月前后的空腹血糖(FPG)、餐后2小时血糖(2hPG)、糖化血红蛋白(HbA1 c)、空腹C肽、餐后2小时C肽、血脂、体重、血压。结果:睡前加用中效胰岛素治疗3个月后,患者的FPG、2hPG、HbA1 c较治疗前明显下降(P <0 . 0 1 ) ,餐后2小时C肽较治疗前明显升高,其差异性有显著性(P <0 .0 1 ) ,而对血脂、体重指数、血压影响不大。结论:对单用口服药效果欠佳的2型糖尿病,睡前加用中效胰岛素治疗效果显著。
Objective: To observe the clinical effect of pre-sleep insulin plus oral hypoglycemic agents in the treatment of type 2 diabetes mellitus. Methods: Forty-five patients with type 2 diabetes who did not receive oral hypoglycemic agents were treated with moderate-effect insulin before bedtime. Fasting plasma glucose (FPG) and 2-hour postprandial blood glucose (2hPG) ), Glycosylated hemoglobin (HbA1 c), fasting C-peptide, 2-hour postprandial C-peptide, lipids, weight, and blood pressure. Results: FPG, 2hPG and HbA1c in patients were significantly lower than those before treatment (P <0.01) after 3 months of bedtime plus middle-acting insulin therapy. C-peptide in 2 hours after meal was significantly higher than that before treatment, The difference was significant (P <0. 01), while the blood lipids, body mass index, blood pressure little effect. Conclusion: Type 2 diabetes mellitus, which is not effective with single oral medication, has significant effect of adding preemptive insulin before going to bed.