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目的 探讨常规剂量与大剂量氨溴索对肺部感染患者Sputum标本采集的影响.方法 选择2014年10月-2016年10月在北京市丰台中西医结合医院急诊科收治的112例肺部感染患者,按入院先后顺序分为大剂量组54例,常规剂量组58例.常规剂量组:氨溴索注射液30 mg静脉注射3次/d;大剂量组:氨溴索注射液330 mg以5.5 mL/h静脉泵入3次/d,于用药后次日晨留取痰液标本.结果 大剂量组标本采集率为92.6%(50/54),常规剂量组为74.1%(43/58);大剂量组标本合格率为82%(41/50),常规剂量组为55.8%(24/43);大剂量组标本阳性率为82.9%(34/41),常规剂量组为50%(12/24),大剂量组患者标本采集率、标本合格率和标本培养阳性率均高于常规剂量组,差异均有统计学意义(P<0.01).结论采用大剂量氨溴索注射液诱导排痰的患者其标本采集率、标本合格率和标本培养阳性率均高于常规剂量组,能更早期、迅速及有效的促进排痰.“,”Objective To investigate the effects of Ambroxol on collection of Sputum samples in patients with pulmonary infections.Methods 112 patients with pulmonary infection were randomly divided into 2 groups to undergo intravenous injection of ambroxol 30 mg ter in die (routine dose group,n=58)or Intravenous infusion of ambroxol 330 mg in 5.5 mi/h t.i.d. (high dose group, n=54). In the morning the next day the sputum coughed up from the deep airway was collected for culture of pathogens and drug-sensitivity test.Results The specimen collection rate,specimen qualified rate, and specimen positive rate of the high dose group were 92.6%, 82.0%, and 82.9% respectively, all significantly higher than those of the routine dose group(74.1%, 55.8%,and 50.0% respectively(P=0.009,0.006,and 0.005 respectively).Conclusion High dose ambroxol effectively promote early and easy expectoration in patients with pulmonary infection.