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目的:Box-Behnken效应面法优化姜黄素微囊的处方,并考察其体外释药特性。方法:以胶药比、胶液浓度和搅拌速度为考察因素,采用复凝聚法,以微囊的载药量、粒径分布、平均粒径为考察指标,用Box-Behnken效应面法优化制备工艺,根据最佳数学模型描绘效应面,选择最佳制备工艺,并进行预测分析。结果:优选的最佳制备工艺为:胶药比为4.5∶1、胶液浓度为30 g/L、搅拌速度为400 r/min,测得姜黄素微囊的载药量为9.64%。囊径在25μm左右,具有一定的缓释作用。结论:模型预测性良好,活性碳可以替代稳定性较差的药物优化工艺,得到了工艺简单可靠、溶出合理的姜黄素微囊处方。
OBJECTIVE: To optimize the formulation of curcumin microcapsules by Box-Behnken effect surface methodology and study its in vitro release characteristics. Methods: The drug-to-drug ratio, the concentration of gum solution and the stirring speed were investigated. The complex agglomeration method was used to investigate the drug loading, particle size distribution and average particle diameter of the microcapsules. The optimal conditions were Box-Behnken surface methodology Craft, draw the effect surface according to the best mathematical model, choose the best preparation technology, and carry on the forecast analysis. Results: The optimum preparation conditions were as follows: the ratio of drug to drug was 4.5:1, the concentration of glue was 30 g / L and the stirring speed was 400 r / min. The drug loading of curcumin microcapsule was 9.64%. Pouch diameter of about 25μm, with a certain slow-release effect. Conclusion: The predictive model is good, activated carbon can replace the poor stability of the drug optimization process, obtained a simple and reliable process, dissolution of curcumin microcapsules prescription.