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糖尿病(diabetes mellitus,DM)是由多种环境因素、遗传因素联合作用导致慢性高血糖状态的全身代谢性疾病,易并发形成心血管、视网膜、肾脏、神经等病变,发病机制复杂,严重危害人类健康。目前DNA损伤、修复在DM及其并发症的发生发展和防治过程中的作用受到重视,现就DNA损伤与修复过程中多聚(ADP核糖)聚合酶[Poly(ADP-ribose)polymerase,PARP]功能、8-羟基鸟嘌呤(8-hydroxy-2’-deoxyguanosine,8-Ohd G)修复通路、X射线修复交叉互补基因(X-ray repair cross-complementing gene,XRCC)多态性变异、Nei核酸内切酶Ⅷ样蛋白1(nei endonucleaseⅧ-like 1,NEIL1)基因多态性变异和Chk基因细胞周期检测点激酶(checkpoint kinase,Chk)多态性变异与DM及并发症的关系展开综述。
Diabetes mellitus (DM) is a systemic metabolic disease caused by a combination of environmental factors and genetic factors in the chronic hyperglycemic state. It is easy to cause cardiovascular, retinal, renal, neurological and other pathological changes. The pathogenesis is complicated and serious harm to human beings health. At present, attention has been paid to the role of DNA damage and repair in the development of DM and its complications and in the prevention and treatment of ADP. In this study, we reviewed the role of poly (ADP-ribose) polymerase [PARP] Function, 8-hydroxy-2’-deoxyguanosine repair pathway, X-ray repair cross-complementing gene polymorphism The relationship between polymorphism of endonuclease VIII-like 1 (NEIL1) gene and Chk mutation of Chk and the relationship between DM and complications was reviewed.