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对实验感染的泡球蚴病小鼠,以丙硫咪唑50mg/k/d给药30～70天。治后虫囊重量较对照组降低75.7～78.9％。实验感染的细粒棘球蚴病小鼠给予相同剂量40～50天,囊重降低48.8～55.4％。从组织学与超微结构观察到囊壁发生退化变性,但虫囊再移植后均生长良好。 13例肝CE与4例肝AE患者,给服丙硫咪唑18mg/k/d。连服30天一疗程,间隔15天后重复给药3～13(平均5.6)疗程。治后6～13个月复查。CE病人中2例治愈,9例获部分有效或改善,2例失败。AE病人中,2例部分有效,2例改善。本文证实该药治疗包虫病有一定效果。
Experimental infection of alveolar hydatid disease mice, to albendazole 50mg / k / d administration of 30 to 70 days. After treatment, the weight of blastocysts was 75.7 ~ 78.9% lower than that of the control group. Experimental infected granulosis mice given the same dose of 40 to 50 days, reducing the weight 48.8 ~ 55.4%. Degeneration and degeneration of the capsule wall were observed from the histology and ultrastructure, but the growth of the worm capsule was good after transplantation. Thirteen patients with liver CE and four patients with liver AE were treated with albendazole 18mg / k / d. Even for 30 days a course of treatment, interval 15 days after repeated administration of 3 to 13 (average 5.6) course of treatment. 6 to 13 months after the review. Two of the CE patients were cured, nine were partially effective or improved, and two failed. Of the AE patients, 2 were partially effective and 2 were improved. This article confirmed that the drug treatment of hydatid disease have a certain effect.