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血浆置换最早在1914年由 Abel 等首次开展,其基本过程是通过体外循环把患者的血浆引出,经血浆分离器,弃去血浆,把细胞成分和所需补充的白蛋白、新鲜血浆等回输到体内,达到清除致病物质的目的。免疫吸附最早由 Terman等用于治疗重症系统性红斑狼疮(SLE),它利用抗原-抗体的生化反应原理,将抗原或抗体固定在载体上制成吸附柱,当血浆流经吸附柱时,血浆中的抗原或抗体被吸附、清除。血浆置换与免疫吸附疗法目前在临床上广泛应用于自身免
The first plasma exchange was first carried out by Abel et al in 1914. The basic process of plasma exchange was to draw out the patient’s plasma by extracorporeal circulation. The plasma was discarded to remove the plasma components, the cell components, the albumin to be replenished, and fresh plasma To the body, to clear the pathogenic substances purpose. Immunoadsorption was first used by Terman et al. For the treatment of severe systemic lupus erythematosus (SLE). It utilizes the antigen-antibody biochemical reaction principle to immobilize the antigen or antibody on the carrier to form an adsorption column. When plasma flows through the adsorption column, plasma The antigen or antibody is adsorbed, cleared. Plasma exchange and immunosuppressive therapy is currently widely used in clinical self-exemption