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在临床药物治疗中,当医生要求对患者给予某药每日3次或4次时,护士并非是按照每日给药次数平均划分剂量间隔时间(Dosing interval),而往往是根据作息时间上的方便安排剂量间隔。如每日给药3次,常常分别安排在8:00、14:00、20:00给予,而不是每8h给药1次(即:8:00、16:00、24:00)。这种给药时间上的差异对维生素类等药物的使用可能影响不大。但是,这种差异有时对某些药物(如抗生素、治疗指数小的药物等)的疗效能产生较大的影响。间隔不当,可能会降低药效,或增加药物不良反应,甚至使药物对机体产生毒性作用。一、剂量间隔对血药浓度的影响
In clinical drug therapy, when a doctor asks for a given drug to a patient three or four times a day, the nurse does not divide the dosage interval by the number of daily dosing intervals, Convenient to arrange dose interval. If administered three times a day, it is often given at 8:00, 14:00, 20:00, rather than once every 8 hours (ie 8:00, 16:00, 24:00). This difference in timing of administration may have little effect on the use of drugs such as vitamins. However, this difference sometimes has a greater impact on the efficacy of certain drugs (such as antibiotics, drugs with a small therapeutic index, etc.). Improperly spaced, may reduce efficacy, or increase adverse drug reactions, and even make the drug toxic effects on the body. First, the dose interval on the plasma concentration