纤维蛋白原是一种丰富的血浆蛋白,它参与凝血反应的最后过程,也叫凝血因子Ⅰ。已发现许多人类纤维蛋白原的遗传变异体,它们大多表现凝血时间延长,有些甚至发生病理学改变。天然的纤维蛋白原(分子量340,000)是由α、β和γ链组成的二聚体。现已阐明所有三个链的氨基酸顺序,由于这些链表现有序列的同源性,已经证明它们是来源于一个共同的原始序列。由于γ链变异体和MNSs Fibrinogen is an abundant plasma protein that participates in the final course of coagulation, also known as factor I. A number of genetic variants of human fibrinogen have been found, most of which exhibit prolonged clotting times and some even undergo pathological changes. Native fibrinogen (MW 340,000) is a dimer composed of alpha, beta and gamma chains. The amino acid sequences of all three chains have now been elucidated, and since these chains exhibit sequence homology, it has been shown that they are derived from a common original sequence. Due to γ ​​chain variants and MNSs