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目的:观察祖师麻止痛喷雾剂对豚鼠的长期毒性,为临床安全用药提供依据。方法:将50只豚鼠随机分为空白对照组、高剂量完整皮肤组、高剂量破损皮肤组、低剂量完整皮肤组、低剂量破损皮肤组,连续给药4周。随时观察记录其一般情况,用药后做血液学及血液生化指标检查,计算脏器系数并进行组织病理学检查。结果:祖师麻止痛喷雾剂各剂量组未见毒性反应,与空白对照组比较差异均无统计学意义(P>0.05),停药后也未见药物延迟性毒性反应。结论:长期给予豚鼠祖师麻止痛喷雾剂无明显毒性,推论临床拟用剂量安全。
Objective: To observe the long-term toxicity of Zushima anesthesia sprays to guinea pigs and provide the basis for clinical safety medication. Methods: Fifty guinea pigs were randomly divided into blank control group, high-dose intact skin group, high-dose damaged skin group, low-dose intact skin group and low-dose damaged skin group for 4 weeks. Observe and record the general situation at any time, do hematology and blood biochemical indicators after treatment, calculate the organ coefficient and histopathological examination. Results: There was no toxic reaction in each dosage group of Zushi Shi Ma pain reliever, which showed no significant difference compared with the blank control group (P> 0.05). Delayed toxic reaction was not observed after the drug was discontinued. Conclusion: Long-term guinea pig angelica analgesic spray no obvious toxicity, corroborating clinical dose safety.