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人免疫缺陷病毒(Human immunodeficiency virus type1,HIV-1)可以在人细胞中复制,但不能在许多非人灵长类动物细胞中复制,其原因可能是HIV-1不能逃避或抵抗这些细胞中存在的种属特异性抗病毒因子。Tetherin是继Trim5α[1]、APOBEC3G[2]后,发现存在于猴子中的第3种抗HIV-1因子。
Human immunodeficiency virus type 1 (HIV-1) can replicate in human cells but can not replicate in many non-human primate cells, probably because HIV-1 can not escape or counteract the presence of these cells Species-specific antiviral agents. Tetherin is the third anti-HIV-1 factor found in monkeys following Trim5α [1], APOBEC3G [2].