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目的探讨他汀类药物治疗冠心病患者的临床疗效及调脂干预效果。方法将唐山工人医院分院内科69例患者随机分为治疗组35例和对照组34例,治疗组口服普伐他汀片,对照组口服鱼油,观察冠心病患者症状、心电图改善情况,并分别于治疗前、后测定血脂水平,组间进行比较分析。结果治疗后治疗组血脂水平与对照组比较明显下降,治疗组冠心病患者症状改善总有效率为94.3%、明显优于对照组的73.5%,治疗组心电图改善总有效率为68.6%、明显优于对照组的41.2%,两组间差异均有统计学意义(P<0.05)。结论他汀类药物降胆固醇作用明显,并且可以显著改善冠心病患者的心电图、症状及预后,应作为冠心病患者治疗的一线用药。
Objective To investigate the clinical efficacy of statins in patients with coronary heart disease and the effect of lipid-lowering intervention. Methods A total of 69 patients in Tangshan Workers’ Hospital were randomly divided into treatment group (35 cases) and control group (34 cases). The treatment group was given pravastatin tablets orally and the control group was orally administered with fish oil. The symptoms and ECG were observed in patients with coronary heart disease. Before and after the determination of serum lipid levels, comparative analysis between groups. Results After treatment, the blood lipid level of the treatment group decreased significantly compared with that of the control group. The total effective rate of the treatment group was 94.3%, which was significantly better than that of the control group (73.5%). The total effective rate of the electrocardiogram improvement group was 68.6% 41.2% of the control group, the differences between the two groups were statistically significant (P <0.05). Conclusions Statins have obvious effect of lowering cholesterol, and can significantly improve the ECG, symptoms and prognosis of patients with coronary heart disease. They should be the first-line treatment for patients with coronary heart disease.