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目的探讨术后辅助化疗对早期高危子宫内膜癌患者预后的影响。方法具有高危因素的早期子宫内膜癌患者213例,术后接受化疗的105例(化疗组),未接受化疗的108例(对照组)。比较两组患者的5年累积生存率。结果化疗组的5年累积生存率为94.2%,高于对照组的84.4%(P<0.05)。分层分析显示,子宫内膜癌的病理类型、分期和分级、淋巴脉管间隙浸润和是否行术后辅助化疗是影响患者预后的独立危险因素(P<0.05)。结论术后辅助化疗可以改善具有高危因素的早期子宫内膜癌患者的预后。
Objective To investigate the effect of postoperative adjuvant chemotherapy on the prognosis of early high-risk endometrial cancer patients. Methods Totally 213 early endometrial cancer patients with high risk factors, 105 patients undergoing chemotherapy (chemotherapy group) and 108 patients without chemotherapy (control group). Five-year cumulative survival was compared between the two groups. Results The 5-year cumulative survival rate was 94.2% in the chemotherapy group compared with 84.4% in the control group (P <0.05). Hierarchical analysis showed that the pathological type, stage and grade of endometrial cancer, lymphovascular space invasion and postoperative adjuvant chemotherapy were the independent risk factors influencing the prognosis of patients (P <0.05). Conclusions Postoperative adjuvant chemotherapy can improve the prognosis of patients with early stage endometrial cancer with high risk factors.