1982年赫梅生首次提出用动物急性累计死亡率法估测药代动力学参数。该法以其简易且通用于估测各种化学物质代谢动力学参数的特点,尤其适用于那些暂无其他方法测定血中浓度的物质,而受到重视和欢迎.但该法所得参数的精密度问题一直未能解决。本文将就此进行探讨,并提出具体的参数精密度求测方案。 In 1982, Hermes first proposed the use of animal acute cumulative mortality method to estimate pharmacokinetic parameters. The method is simple and commonly used in the estimation of various chemical substances, the characteristics of the kinetic parameters, especially for those who no other way to determine the concentration of blood substances, and has received the attention and welcome.But the method parameters obtained precision The problem has not been solved. This article will explore this and put forward specific parameters of precision measurement program.