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目的:观察慢性充血性心力衰竭(CHF)患者在用利尿剂强心甙类血管紧张素转换酶抑制剂(ACEI)等基础上加用β受体阻滞剂后,临床疗效及心功能的改善情况。方法:将108例CHF患者随机分成两组,对照组常规治疗,观察组在此基础上加用β受体阻滞剂(酒石酸美托洛尔)治疗。观察二组治疗前后心功能改善情况及心率、血压,左室射血分数(LVEF)、左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)。结果:观察组有效率达93%。两组患者在治疗后较治疗前LVESD、LVEDD、LVEF均有明显改善(均P<0.05),观察组治疗后LVEF、LVESD、LVEDD与对照组治疗比较改善显著(P<0.01)。结论:β受体阻滞剂可明显提高LVEF改善心功能,且安全有效,可以长期应用。
OBJECTIVE: To observe the clinical efficacy and improvement of cardiac function in patients with chronic congestive heart failure (CHF) after adding β-blockers on the basis of diuretic cardiotonic glycosides such as angiotensin converting enzyme inhibitor (ACEI) Happening. Methods: One hundred and eight patients with CHF were randomly divided into two groups. Patients in the control group were treated routinely. The observation group was treated with β-blocker (Metoprolol tartrate). The improvement of heart function, heart rate, blood pressure, left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD) were observed before and after treatment in two groups. Results: The observation group, the effective rate of 93%. The LVESD, LVEDD and LVEF in both groups were significantly improved after treatment (all P <0.05). The LVEF, LVESD and LVEDD in the observation group improved significantly compared with the control group after treatment (P <0.01). Conclusion: β-blockers can significantly improve LVEF improve cardiac function, and safe and effective, long-term application.