【摘 要】
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Ran, a member of the Ras GTPase superfamily,is a multifunctional protein and abundant in the nucleus.Many evidences suggest that Ran and its interacting protein
【机 构】
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Department of Cell Bioegy and Genetics
【基金项目】
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教育部留学回国人员科研启动基金;国家自然科学基金;面向21世纪教育振兴行动计划(985计划);国家重点基础研究发展计划(973计划)
论文部分内容阅读
Ran, a member of the Ras GTPase superfamily,is a multifunctional protein and abundant in the nucleus.Many evidences suggest that Ran and its interacting proteins are involved in multiple aspects of the cell cycle regulation.So far it has been conformed that Ran and its interacting proteins control the nucleocytoplasmic transport, the nuclear envelope (NE) assembly, the DNA replication and the spindle assembly, although many details of the mechanisms are waiting for elucidation. It has also been implicated that Ran and its interacting proteins are involved in regulating the integrity of the nuclear structure, the mRNA transcription and splicing, and the RNA transport from the nucleus to the cytoplasm. In this review we mainly discuss the mechanisms by which Ran and its interacting proteins regulate NE assembly, DNA replication and spindle assembly.
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