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目的探讨本院内药物不良反应的原因、特点以及预防措施。方法选取2012年5月—2014年5月本院内发生的50例用药不良反应报告,分别根据病患情况、药物类别、累及部位以及用药途径进行分析研究,总结其发生的特征并给予针对性预防建议。结果 50例不良反应中女性比例高于男性,差异有统计学意义(P<0.05)。临床应用药物中抗感染药品高于其他类型,差异有统计学意义(P<0.05)。不良反应累及部位中消化系统最多,与其他部位比较,差异有统计学意义(P<0.05)。而采用静脉滴注方式给药患者不良反应发生率高于其他途径,差异有统计学意义(P<0.05)。结论药物不良反应的发生与患者基本情况、用药类别、途径等均存在一定程度的相关性,临床给药时需根据患者实际情况给予足够重视,进而提高安全程度,降低危险度。
Objective To investigate the causes, characteristics and preventive measures of adverse drug reactions in our hospital. Methods Fifty adverse drug reactions (ADRs) occurred in our hospital from May 2012 to May 2014 were analyzed and analyzed according to the patient’s condition, the type of drug, the site of involvement and the route of administration. The characteristics of the adverse reactions were summarized and targeted prevention Suggest. Results 50 cases of adverse reactions in women than in men, the difference was statistically significant (P <0.05). Anti-infective drugs in clinical application of drugs higher than the other types, the difference was statistically significant (P <0.05). Adverse reactions involving the most part of the digestive system, compared with other parts, the difference was statistically significant (P <0.05). The incidence of adverse reactions in patients receiving intravenous infusion was higher than other ways, the difference was statistically significant (P <0.05). Conclusions The occurrence of ADR is related to the basic situation, the type and route of drug use, etc. There is a certain degree of correlation between the occurrence of adverse drug reactions and the patients. The clinical application should be given sufficient attention according to the actual situation of the patients so as to improve the safety and reduce the risk.