目的研究紫金砂的化学成分。方法药材采用体积分数80%乙醇提取,氯仿萃取,利用硅胶柱,RP-18反相柱,Sepha-dex LH-20凝胶柱分离纯化,并根据理化性质和波谱数据进行结构鉴定。结果分离鉴定13个化合物,分别为异欧前胡素(1)、水合氧化前胡素内酯(2)、拐芹色原酮(3)、佛手柑内酯(4)、欧前胡素(5)、ledebouriellol(6)、二氢欧山芹素(7)、isopimp-inellin(8)、osthol(9)、3′(R)-+-亥茅酚(10)、oxypeucedanin ethanolate(11)、β-谷甾醇(12)、豆甾醇(13)。结论化合物6~11为首次从紫金砂中分离得到,其中化合物6、11为首次从当归属植物中分离得到。 Objective To study the chemical composition of Zijin sand. Methods The crude drug was extracted with 80% ethanol by volume fraction and extracted with chloroform. The constituents were isolated and purified by silica gel column, RP-18 reverse phase column and Sephadex LH-20 gel column. The structures were elucidated on the basis of physico-chemical properties and spectral data. Results Thirteen compounds were isolated and identified as isoimperatorin (1), hydantoingenin (2), procyclone (3), bergapten (4), imperatorin (5) ledebouriellol (6) dihydroperoxide (7) isopimp-inellin (8) osthol (9) β-sitosterol (12), stigmasterol (13). Conclusions Compounds 6-11 were isolated from Zijin for the first time, and compounds 6 and 11 were isolated from Angelica for the first time.