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背景 血液成份中含有的白细胞是免疫损伤和免疫缺陷受者感染巨细胞病毒(CMV)最可能来源,这一点已被人们接受。研究设计和方法 为确认白细胞滤器能否有效防止CMV高流行区域输血新生儿感染CMV,进行了一次随机研究。所有供者的血液在使用前经照射以防止输血后发生移植物抗宿主病。通过血清转化(产生IgM抗CMV)和CMV-DNA分离监测受者CMV感染情况。结果 33例输注过滤血液的婴儿中有3例(9％)以及1
It is accepted that leukocytes contained in blood components of the background are the most likely source of CMV infection in immunocompromised and immunocompromised recipients. Study Design and Methods A randomized study was conducted to determine whether a leukocyte filter can effectively prevent CMV infection in neonates with transfusion in CMV-endemic areas. All donor blood was irradiated before use to prevent graft-versus-host disease after transfusion. Recipient CMV infections were monitored by seroconversion (production of IgM anti-CMV) and CMV-DNA isolation. Results Of the 33 infants who received filtered blood, 3 (9%) and 1 were infants