前炎症状态(proinflammation)是多种疾病,尤其是感染或免疫相关疾病早期的一种病理生理状态,近年来引起一些研究者的关注,前炎症因子的概念在近期出版的国外文献中频频出现.从前炎症状态角度对白血病和白血病细胞进行初步探索,获得有意义的结果,如急性髓细胞白血病患者的前炎症因子白介素-18表达明显升高,上调基质金属蛋白酶及组织特异性抑制物的表达,从而增强白血病细胞的侵袭力,患者预后不良,反映了白血病被忽视的一个方面.从前炎症状态角度进行观察,拓宽了肿瘤和白血病研究的视野. Proinflammation is a pathophysiological condition of many diseases, especially in the early stage of infection or immune-related diseases. In recent years, it has attracted the attention of some researchers. The concept of pro-inflammatory cytokines frequently appears in the foreign literature recently published. From the perspective of the former inflammatory state of leukemia and leukemia cells were initially explored to obtain meaningful results, such as acute myeloid leukemia in patients with pre-inflammatory factor interleukin-18 expression was significantly increased, increased matrix metalloproteinase and tissue-specific inhibitor expression, Thereby enhancing the invasiveness of leukemia cells, patients with poor prognosis, reflecting one aspect of the neglected leukemia from the perspective of the previous inflammation status, broaden the field of vision of cancer and leukemia research.