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目的探讨《威廉姆斯产科学》(24版)推荐的4项孕期血脂参考值范围是否适合中国孕妇。方法选取2014年6~12月在北京市通州区妇幼保健院生产的足月单胎孕妇进行问卷调查,最终符合纳入本研究病例共计2 117例。将1 045例正常孕妇血脂排序,求出相应百分位数,建立血脂正常值参考区间。分析《威廉姆斯产科学》(24版)推荐的4项正常孕妇血脂水平参考范围和本研究中确定的参考值范围的一致性(κ值)。结果 4项血脂指标在各期均具有一致性(P<0.05)。孕早期:TC_κ=0.571,TG_κ=0.464,HDL_κ=0.193,LDL_κ=0.946;孕中期:TC_κ=0.756,TG_κ=0.752,HDL_κ=0.472,LDL_κ=0.815;孕晚期:TC_κ=0.156,TG_κ=0.765,HDL_κ=0.455,LDL_κ=0.509。结论《威廉姆斯产科学》(24版)推荐的4项正常孕妇血脂参考范围在一定程度上适用于国内孕妇。
Objective To investigate whether the four reference ranges of serum lipids recommended by Williams Faculty of Obstetrics and Gynecology (24th edition) are suitable for Chinese pregnant women. Methods A total of 21 117 pregnant women with full-term singletons who were born in Tongzhou District Maternal and Child Health Hospital of Beijing from June to December 2014 were selected for questionnaire survey. The lipids of 1045 normal pregnant women were sorted, the corresponding percentiles were calculated, and the reference range of normal blood lipids was established. Analysis of the consistency of the reference range of 4 normal pregnant women’s lipid levels recommended by Williams Faculty of Obstetrics (24th Edition) and the reference range established in this study (κ). Results The four indexes of blood lipids were consistent in all stages (P <0.05). The first trimester of pregnancy: TC_κ = 0.571, TG_κ = 0.464, HDL_κ = 0.193, LDL_κ = 0.946; second trimester: TC_κ = 0.756, TG_κ = 0.752, HDL_κ = 0.472, LDL_κ = 0.815; third trimester: TC_κ = 0.156, TG_κ = 0.765, HDL_κ = 0.455, LDL_κ = 0.509. Conclusion The reference range of 4 normal pregnant women recommended by Williams Faculty of Obstetrics and Gynecology (24th Edition) is suitable for pregnant women in China to some extent.