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本研究选用Ames试验、骨髓染色体畸变分析和皮肤致癌实验优化组合,评价苯乙烯的致突变性和致癌性。结果表明苯乙烯经代谢活化后引起TA_(100)沙门氏突变株回复突变,证明苯乙烯属于碱基取代型致突变物。骨髓染色体畸变分析表明340mg/kg剂量下的苯乙烯引起明显的小鼠骨髓染色体畸变。小鼠皮肤致癌实验中最高剂量组只出现1例阳性。结果提示苯乙烯是致突变物和可疑致癌物。本研究为苯乙烯安全性评价,制定卫生标准提供了实验数据。
In this study, Ames test, bone marrow chromosome aberration analysis and skin cancer experiments were optimized to evaluate the mutagenicity and carcinogenicity of styrene. The results showed that after the metabolism of styrene by TA_ (100) salmonella mutations caused by back mutations, that styrene is a base-substitution-induced mutants. Analysis of bone marrow chromosome aberrations showed that styrene at 340 mg / kg caused significant bone marrow chromosome aberrations in mice. In the highest dose group of mouse skin carcinogenesis experiment, only one case was positive. The results suggest that styrene is mutagenic and suspicious carcinogens. This study provided experimental data for the safety assessment of styrene and the development of health standards.