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目的:比较利培酮与氯氮平对血糖的影响。方法:将我科200例符合CCMD-3精神分裂症诊断标准的患者随机分为两组,采用氯氮平和利培酮治疗,疗程12W,治疗前及治疗第2、4、6、8、12W末分别进行血糖检查。结果:利培酮组血糖发生改变8例(8%),氯氮平组21例(21%),两组比较,差异有统计学意义(P<0.05)。随着治疗的进行,血糖尚有明显增高趋势。结论:利培酮对患者血糖的影响明显低于氯氮平,但临床中也应提高注意。
Objective: To compare the effects of risperidone and clozapine on blood glucose. Methods: 200 cases of CCMD-3 schizophrenia diagnostic criteria in our department were randomly divided into two groups, treated with clozapine and risperidone, the treatment of 12W, before treatment and the treatment of 2,4,6,8,12 W At the end of the blood glucose test. Results: The changes of blood glucose in risperidone group were found in 8 cases (8%) and in 21 cases (21%) in clozapine group. The difference was statistically significant (P <0.05). With the progress of treatment, there is a clear trend of increasing blood sugar. Conclusion: The effect of risperidone on blood glucose is significantly lower than clozapine, but attention should be paid in clinic.