目的通过对妊娠期妇女风疹病毒(RV)Ig M、Ig G抗体水平调查,为预防妊娠期风疹病毒感染和胎儿先天性风疹综合征(CRS)提供参考依据。方法采用酶联免疫吸附试验(ELISA)方法检测孕妇RV-Ig M和RV-Ig G抗体,并按照不同年龄、孕期进行分组和数据分析。结果 359例孕妇风疹Ig M抗体阳性率为1.11%,风疹Ig G抗体阳性率和几何平均浓度(GMC)分别为72.98%和24.52IU/m L;孕妇风疹Ig G抗体水平随着年龄的增长呈现下降趋势,而孕妇对RV易感率随年龄增长有明显增高趋势,≥35年龄组孕妇风疹Ig G抗体阳性率和GMC明显低于35岁以下年龄组;早孕期RV易感率(33.33%)明显高于中孕(24.86%)和晚孕期(26.98%)。结论建议加强风疹及CRS的监测工作,尤其需加强对35岁以上生育的女性人群进行监测和风疹疫苗强化免疫,为做好优生优育,提高人口出生素质提供科学依据。 OBJECTIVE: To investigate the levels of IgM and IgG antibodies in rubella virus (RV) in pregnant women in order to provide references for the prevention of rubella virus infection in pregnancy and congenital rubella syndrome (CRS) in fetus. Methods The serum levels of RV-Ig M and RV-Ig G in pregnant women were detected by enzyme-linked immunosorbent assay (ELISA) and divided into groups and data according to different age and pregnancy. Results The positive rate of rubella Ig M antibody in 359 pregnant women was 1.11%. The positive rate and geometric mean concentration (GMC) of rubella Ig G were 72.98% and 24.52 IU / ml respectively. The level of Ig G antibody in pregnant women was increased with age The prevalence of rubella Ig G antibody in pregnant women ≥ 35 years old and GMC was significantly lower than those under 35 years old; the susceptibility rate of RV in early pregnancy was 33.33% Significantly higher than the second trimester (24.86%) and late pregnancy (26.98%). Conclusions It is suggested to strengthen the monitoring of rubella and CRS. In particular, it is necessary to strengthen the monitoring and rubella vaccine immunization for female population over 35 years of age and provide scientific basis for good prenatal and postnatal care and improvement of birth quality.