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神经肽Y对下丘脑-垂体-性腺轴有调节作用。在大鼠家兔的实验中,有雌二醇(E_2)时,它刺激黄体生成激素释放激素(LHRH)分泌及LH释放;而在去性腺动物,则降低LH分泌频率和分泌峰。去卵巢猴第三脑室注射神经肽Y,使平均LH水平、分泌脉冲及幅度下降;以雌激素处理,并不能使之转化为刺激效应。神经肽Y对灵长类的刺激效应似不依赖于性类固醇的存在;但也有报道,小剂量E_2使神经肽Y对LHRH分泌的刺激效应易于发生。在卵巢血管、间质、卵泡外壁及周边组织大量含有神经肽Y。人卵巢神经肽
Neuropeptide Y on the hypothalamus - pituitary - gonadal axis regulation. In the experiments of rat and rabbit, estradiol (E_2) stimulated the secretion of LHRH and LH, while in gonadotrophic it decreased the frequency of LH secretion and secretion. Intranial ovariectomized third ventricle injection of neuropeptide Y, so that the average LH levels, pulse secretion and amplitude decreased; estrogen treatment, and can not make it into a stimulating effect. Neuropeptide Y priming effects on primates seem to be independent of the presence of sex steroids; however, it has also been reported that the stimulation of neuropeptide Y on LHRH secretion is prone to occur at low doses of E_2. In ovarian blood vessels, stroma, follicular outer wall and surrounding tissue contains a large number of neuropeptide Y. Human ovarian neuropeptide