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头孢唑肟(ceftizoxime,日本藤泽药品工业公司,商品名Epocelin)为半合成的第三代头孢菌素。它对大多数革兰阳性和阴性菌、需氧和厌氧菌有强抗菌活性,用于治疗复发性重症化脓-脓毒性疾病具有很高疗效。 头孢唑肟的化学结构,如同其它头孢菌素(头孢噻肟、头孢曲松、头孢甲肟)一样,在分子中具有氨基-噻唑-甲氧亚氨基,因此,它对质粒和染色体介导的β-内酰胺酶稳定,以及对PBP有高度亲和力。
Ceftizoxime (Japan Fujisawa Pharmaceutical Co., Ltd., Epocelin) is a semisynthetic third-generation cephalosporin. It has strong antibacterial activity against most Gram-positive and -negative bacteria, aerobic and anaerobic bacteria and is highly effective in treating recurrent severe suppurative-septic diseases. The chemical structure of ceftizoxime, like other cephalosporins (cefotaxime, ceftriaxone, cefmenoxime), has an amino-thiazole-methoxyimino group in the molecule and therefore its effect on plasmid and chromosome-mediated β-lactamase is stable, and has a high affinity for PBP.