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目的了解太原地区2005-2006年流行性感冒(流感)在儿童急性呼吸道感染中的分布并确定当年的流感病毒优势株。方法采集山西省人民医院门诊急性呼吸道感染患儿的标本87份,分别经传代犬肾(MDCK)细胞分离病毒和血凝抑制试验(HI)鉴定流感病毒型别;并于2005年10月和2006年3月(流感流行前、后期)采集415份非呼吸道疾病的儿童及部分成年人血清标本进行了流感HI抗体检测。结果从87份流感样患儿血清标本中分离出甲1型流感病毒7株,阳性率8.04%。415份血清标本中0～岁、3～岁及7～18岁组甲1型流感HI抗体阳性率及几何平均滴度流感流行后期均明显高于流行前期,差异有统计学意义(P<0.01)。结论2005-2006年冬春太原地区儿童流感流行以甲1型为主。
Objective To understand the distribution of influenza (influenza) in children with acute respiratory infection in 2005-2006 in Taiyuan area and to determine the dominant strains of influenza virus in that year. Methods Eighty-seven children were collected from outpatients with acute respiratory tract infection in Shanxi Provincial People’s Hospital. Influenza virus was identified by transmission electron microscopy (MDCK) and hemagglutination inhibition test (HI) respectively. In October 2005 and 2006 In March of this year (before and after the flu epidemic), 415 serum samples of non-respiratory disease children and some adults were collected for HI antibody detection. Results A total of 7 influenza A (H1NIV) isolates were isolated from 87 influenza samples, the positive rate was 8.04%. The positive rate and geometric mean titers of HI antibody in the serum samples from 0 to 3 years, 3 to 7 years old and 7 to 18 years old in 415 serum samples were significantly higher than those in the pre-epidemic period (P <0.01) ). Conclusion The prevalence of influenza in children in Taiyuan from 2005 to 2006 was mainly Type A 1.