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目的:观察在常规西药基础上加用平肝胶囊对阴虚阳亢型高血压病患者血压晨峰的影响。方法:将83例患者随机分为治疗组42例和对照组41例,2组均用常规抗高血压西药(苯磺酸氨氯地平片、氯沙坦钾片)治疗,治疗组另加平肝胶囊。观察治疗前后2组患者动态血压、中医证候积分的变化。结果:治疗后,2组眩晕、头痛、腰酸、膝软、心悸、失眠、耳鸣、健忘等证候较治疗前改善,2组中医证候总积分均较治疗前下降,差异均有统计学意义(P<0.01);治疗组中医证候总积分低于对照组,差异有统计学意义(P<0.01)。治疗组总有效率高于对照组,差异有统计学意义(P<0.05)。2组24 h动态血压监测清晨收缩压(SBP)、血压晨峰均低于治疗前(P<0.01),治疗组清晨SBP、血压晨峰均低于对照组(P<0.01)。结论:在常规西药基础上加用平肝胶囊能有效改善高血压病患者的阴虚阳亢症状,且能减小血压晨峰幅度。
OBJECTIVE: To observe the effect of Pinggan Capsule on the morning peak of blood pressure in patients with yin-deficiency-yang hyperactivity disorder on the basis of conventional western medicine. Methods: Eighty-three patients were randomly divided into treatment group (n = 42) and control group (n = 41). Both groups were treated with conventional antihypertensive western medicine (amlodipine besylate tablets and losartan potassium tablets) Liver capsule. Observed before and after treatment in two groups of patients with ambulatory blood pressure, TCM syndrome score changes. Results: After treatment, two groups of syndromes such as dizziness, headache, backache, knee softness, heart palpitations, insomnia, tinnitus and forgetfulness improved compared with those before treatment. The total score of TCM syndromes in the two groups decreased compared with before treatment, with statistical significance (P <0.01). The total score of TCM syndrome in the treatment group was lower than that in the control group, with significant difference (P <0.01). The total effective rate in the treatment group was higher than that in the control group, with significant difference (P <0.05). The systolic blood pressure (SBP) and blood pressure morning peak of 24h ambulatory blood pressure monitoring in 24 hours in both groups were lower than those before treatment (P <0.01). The SBP and morning peak of morning blood pressure were lower in the treatment group than in the control group (P <0.01). Conclusion: The addition of Pinggan Capsule on the basis of conventional western medicine can effectively improve the symptoms of yin deficiency and hyperactivity in hypertensive patients, and can reduce the amplitude of morning sickness of blood pressure.