University Inspirational Speech(UIS),as a significant part of American’s higher education,is considered as an encouraging,convincing and motivating lesson to students.UIS might have a great effect on student’s outlook of life,helping them to grow as adults armed with noble ideals and entrepreneurial spirits.In order to convey the spirit of original speakers,it is crucial to choose a proper translation theory as a direction.Based on Skopos theory,the paper studied 2014 American UIS translation from the aspect of three rules of Skopos theory,presenting the application of the theory in translation process and to find out how the Skopos theory guides a translation process. University Inspirational Speech (UIS), as a significant part of American's higher education, is considered as an encouraging, convincing and motivating lesson to students. UIS might have a great effect on student's outlook of life, helping them to grow as adults armed with noble ideals and entrepreneurial spirits.In order to convey the spirit of the original speakers, it is crucial to choose a proper translation theory as a direction. Based on Skopos theory, the paper studied 2014 American UIS translation from the aspect of three rules of Skopos theory, presenting the application of the theory in translation process and to find out how the the Skopos theory guides a translation process.