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目的 探讨基质金属蛋白酶(matrix metalloproteinase,MMP)在人脑星形细胞瘤侵袭、转移中的作用。方法 用免疫组织化学方法(S-P法)检测了45例人脑星形细胞瘤组织中MMP-2、MMP-7、MMP-9的表达情况。结果 Ⅲ、Ⅳ级中MMP-2、MMP-9蛋白表达要明显高于Ⅰ、Ⅱ级,而MMP-7在部分Ⅳ级星形细胞瘤中过度表达,而在Ⅰ、Ⅱ、Ⅲ级中无表达。结论MMP-2、MMP-7、MMP-9蛋白的表达与星形细胞瘤的恶性程度有关,其高表达可能与星形细胞瘤的侵袭、转移等恶性生物学行为有关,并有可能成为星形细胞瘤恶性程度、侵袭能力的判断指标。
Objective To investigate the role of matrix metalloproteinase (MMP) in invasion and metastasis of human astrocytoma. Methods The expression of MMP-2, MMP-7 and MMP-9 in 45 human astrocytoma tissues was detected by immunohistochemistry (S-P method). Results The expressions of MMP-2 and MMP-9 in stage Ⅲ and Ⅳ were significantly higher than those in stage Ⅰ and Ⅱ, while MMP-7 was overexpressed in stage Ⅳ astrocytoma, while in stage Ⅰ, Ⅱ and Ⅲ expression. Conclusion The expression of MMP-2, MMP-7 and MMP-9 is related to the degree of malignancy of astrocytomas. The overexpression of MMP-2, MMP-7 and MMP-9 may be related to the malignant biological behaviors such as invasion and metastasis of astrocytomas. Astrocytoma malignancy, invasive ability to determine indicators.