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目的探讨路氏润燥汤对原发性干燥综合征眼干症状的影响。方法将116例原发性干燥综合征气阴两虚型患者随机分为治疗组和对照组,每组58例,治疗组予中药路氏润燥汤,对照组予硫酸羟氯喹,治疗3个月后观察两组患者眼干症状VAS评分、中医证候积分、泪液及免疫、炎性指标改善情况,评价临床疗效。结果治疗组治疗后眼干症状VAS评分与治疗前比较,差异有统计学意义(P<0.05),对照组治疗前后比较差异无统计学意义(P>0.05);两组中医证候眼干症状积分治疗前后比较差异均有统计学意义(P<0.05);对照组血清免疫球蛋白IgG治疗前后比较,差异有统计学意义(P<0.05);两组吸墨试验、血清ANA、SSA、SSB、类风湿因子RF、血沉ESR治疗前后和组间比较,差异无统计学意义(P>0.05)。结论路氏润燥汤对于原发性干燥综合征患者眼干症状改善明显,对泪液分泌、免疫及炎性指标改善不显著。
Objective To investigate the effect of Luoshi Runzao decoction on the dry eye symptoms of Sjogren’s syndrome. Methods One hundred and sixty-six patients with primary Sjogren’s syndrome were randomly divided into treatment group and control group, with 58 cases in each group. The treatment group was treated with Luoshi Runzao decoction and the control group with hydroxychloroquine sulfate. Three Month after the observation of two groups of patients with symptoms of dry eye VAS score, TCM syndrome score, tear and immune, inflammatory indicators to improve the situation, evaluate the clinical efficacy. Results After treatment, the score of VAS in the treatment group was statistically different from that before treatment (P <0.05), but there was no significant difference in the control group before and after treatment (P> 0.05) There were significant differences between before and after treatment (P <0.05); serum immunoglobulin IgG in control group before and after treatment was significantly different (P <0.05); two groups of ink absorption test, serum ANA, SSA, SSB , Rheumatoid factor RF, erythrocyte ESR before and after treatment and between groups, the difference was not statistically significant (P> 0.05). Conclusion Luoshi Runzao Decoction for patients with primary Sjogren’s symptoms improved significantly, tear secretion, immune and inflammatory indicators did not improve significantly.