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目的:观察天麻素注射液治疗系统性眩晕的临床疗效及安全性。方法:60例眩晕患者随机分为观察组和对照组,每组30例。观察组给予天麻素注射液600 mg,ivd,qd,对照组予前列地尔注射液10μg,iv,qd,疗程均为14 d。治疗结束后,评价两组患者的治疗总有效率、椎基底动脉血流动力学变化和药品不良反应发生率。结果:观察组总有效率为96.7%,明显高于对照组的76.7%(P<0.01)。两组中枢性眩晕患者的椎-基底动脉血流峰值速度均较治疗前明显降低(P<0.05或P<0.01),且观察组明显低于对照组(P<0.05或P<0.01)。两组治疗期间未发生明显不良反应。结论:天麻素注射液能有效、安全的改善系统性眩晕患者的临床症状,值得临床推广应用。
Objective: To observe the clinical efficacy and safety of gastrodin injection in the treatment of systemic vertigo. Methods: Sixty patients with vertigo were randomly divided into observation group and control group, 30 cases in each group. The observation group was given gastrodin injection 600 mg, ivd, qd, the control group was treated with alprostadil 10μg, iv, qd, treatment for 14 d. After treatment, the total effective rate of the two groups of patients, vertebrobasilar hemodynamic changes and adverse drug reactions were evaluated. Results: The total effective rate in the observation group was 96.7%, significantly higher than 76.7% in the control group (P <0.01). The vertebrobasilar velocity peak velocity in both groups was significantly lower than that before treatment (P <0.05 or P <0.01), and the observation group was significantly lower than the control group (P <0.05 or P <0.01). No significant adverse reactions occurred during the two groups. Conclusion: Gastrodin injection can effectively and safely improve the clinical symptoms of patients with systemic vertigo, which is worthy of clinical application.